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Want to Get Involved In Research?

[su_heading size="15" margin="0"]The BioInnovation Group is an undergraduate-run research organization aimed at increasing undergraduate access to research opportunities. We have many programs ranging from research project teams to skills training (BIG-RT) and Journal Club.

If you are an undergraduate interested in gaining research experience and skills training, check out our website (https://bigucd.com/) to see what programs and opportunities we have to offer. In order to stay up to date on our events and offerings, you can sign up for our newsletter. We look forward to having you join us![/su_heading]

Newest Posts

May the Odds Ever be in Your Favor

By Rayan Kaakati, Neurobiology, Physiology, and Behavior

Being born female automatically registers you in a game of Russian roulette: one out of eight women will have invasive breast cancer during their lives. Breast cancer is a disease that starts in the tissues of the breast and is statistically fatal for about one in thirty-six women (Breast Cancer Facts), but that does not mean it is a walk in the park for its survivors or even for women who end up not developing the disease. (more…)

A Breakthrough in Breast Cancer Treatment

 Exciting, new gene therapy treatments for breast cancer are on the verge of making a breakthrough. With proper funding, these procedures could reduce the need for the surgical removal of organs.

By Rayan Kaakati, Neurobiology, Physiology, and Behavior

Being born female automatically enters one in a game of Russian roulette: About 1 in 8 women will develop invasive breast cancer over the course of their lifetime; for American women, breast cancer is the second leading cause of death (U.S. Breast Cancer Statistics).

Breast cancer is a disease that starts in the tissues of the breast and is statistically fatal for one in thirty-two women (Breast Cancer Facts). Many women, throughout recorded history, have succumbed to this malignant disease. Rapid advancements in research have been very promising for cancer cell-targeting medications and for gene modification techniques.

Medicine in the twenty-first century is still resorting to what the ancient Chinese and Arab doctors used to practice: “If cancerous, cut it out if possible,” or in current-day terms, order a “lumpectomy” or a “mastectomy” (if the entire breast is to be removed). In recent years, a toxic chemo “smoothie” and an intensive radiation regimen have been added, coupled with hormone therapy.  While these medical procedures are credited with saving thousands of lives, they are still primitive compared to current, promising research works.

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From Embryo to Tumor: the widespread applications of Epithelial-Mesenchymal Transition

By Briga Mullin, Biochemistry and Molecular Biology, ’15

What do a smoker, a two week old embryo, a child with a broken wrist, and a metastatic tumor all have in common? While these are a diverse group of conditions, they all have cells that are experiencing the same process known as epithelial-mesenchymal transition (EMT). Mesenchymal cells are non-polarized, mobile, invasive, and their main function is to secrete extracellular  matrix. In contrast, epithelial cells form our skin and the linings of our internal organs. They are normally polarized which means they have a directional structure and are uniformly oriented and are attached to a membrane to form a layer of epithelial tissue.  Under certain conditions an EMT will occur and epithelial cells will change  their transcription patterns, produce new proteins, destroy the basal membrane they are attached to, and totally convert their phenotype to become motile  mesenchymal cells.  EMT can be triggered by a variety of conditions and can yield very beneficial or extremely detrimental results depending on the circumstances. (more…)